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KMID : 0352519840210030039
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Korea Univercity Medical Journal
1984 Volume.21 No. 3 p.39 ~ p.46
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The effect of garlic on pathological damdgus of restis due to cadmium poisoning
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李鶴燮/Lee, Hack-Sup
裵恩相/車喆煥/Bae, Eun-Sang/Cha, Chul-Whan
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Abstract
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The garlic contains, along with many kinds of organic compounds, some allylsulfides, amino acids, thiolactic acid, glutathione and some vitamins has been expected to yield the effect of detoxication of heavy metal poisoning by forming thiochelate compounds when reacting with heavy metals in living bodies.
To examine this hypothesis, especially for the effect of garlic on the detoxication of Cd-poisoning in testis, one of the most sensitive target organs of Cd-poisoning, a total of 60 albino rats were sampled as experimental animals and devided into six groups: a group given with only 100ppm cadmium; one given 3.35% garlic; two groups given with 1.70% and 6.67 % garlic in addition to 100ppm cadmium; one given with 400ppm garlic oil and a group of controls.
After rearing the rats with different meals and water as indicated above for 12 weeks, alkaline phosphatase activity, cadmium content in testis and pathological changes in testicular tissue were measured and observed to have the following results;
The group given with 6.67% garlic in addition to 100ppm cadmium showed significant decrease of toxic changes due to cadmium poisoning in terms of alkaline phosphatase activity, cadmium accumulation in testis, and pathological change of testicular tissues.
On the other hand, the group given 100ppm cadmium only showed significantly higher contents of cadmium in testis, more decrease of alkaline phosphatase activity and definite pathological findings of hydropic degeneration and necrosis with atrophy in seminiferous: tubules, and degenerative changes in germinal epithelium of testis.
The group given with 400ppm garlic oil in addition to cadmium showed in midline reaction
in every aspect of the above toxic changes.
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KEYWORD
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